diff --git a/src/datajoint/declare.py b/src/datajoint/declare.py
index eaea163b8..7b21b8ede 100644
--- a/src/datajoint/declare.py
+++ b/src/datajoint/declare.py
@@ -25,13 +25,9 @@
     "float32": (r"float32$", "float"),
     "float64": (r"float64$", "double"),
     "int64": (r"int64$", "bigint"),
-    "uint64": (r"uint64$", "bigint unsigned"),
     "int32": (r"int32$", "int"),
-    "uint32": (r"uint32$", "int unsigned"),
     "int16": (r"int16$", "smallint"),
-    "uint16": (r"uint16$", "smallint unsigned"),
     "int8": (r"int8$", "tinyint"),
-    "uint8": (r"uint8$", "tinyint unsigned"),
     "bool": (r"bool$", "tinyint"),
     # UUID (stored as binary)
     "uuid": (r"uuid$", "binary(16)"),
diff --git a/src/datajoint/jobs.py b/src/datajoint/jobs.py
index 70c24f354..071c56783 100644
--- a/src/datajoint/jobs.py
+++ b/src/datajoint/jobs.py
@@ -155,7 +155,7 @@ def _generate_definition(self) -> str:
     {pk_lines}
     ---
     status          : enum('pending', 'reserved', 'success', 'error', 'ignore')
-    priority        : uint8
+    priority        : int8
     created_time=CURRENT_TIMESTAMP(3) : datetime(3)
     scheduled_time=CURRENT_TIMESTAMP(3) : datetime(3)
     reserved_time=null  : datetime(3)
@@ -165,8 +165,8 @@ def _generate_definition(self) -> str:
     error_stack=null : <blob>
     user=""         : varchar(255)
     host=""         : varchar(255)
-    pid=0           : uint32
-    connection_id=0 : uint64
+    pid=0           : int32
+    connection_id=0 : int64
     version=""      : varchar(64)
     """
 
diff --git a/src/datajoint/version.py b/src/datajoint/version.py
index c04a26728..98a5f2b93 100644
--- a/src/datajoint/version.py
+++ b/src/datajoint/version.py
@@ -1,4 +1,4 @@
 # version bump auto managed by Github Actions:
 # label_prs.yaml(prep), release.yaml(bump), post_release.yaml(edit)
 # manually set this version will be eventually overwritten by the above actions
-__version__ = "2.0.0a21"
+__version__ = "2.0.0a22"
diff --git a/tests/integration/test_hidden_job_metadata.py b/tests/integration/test_hidden_job_metadata.py
index c86f32d9d..bcf56dde7 100644
--- a/tests/integration/test_hidden_job_metadata.py
+++ b/tests/integration/test_hidden_job_metadata.py
@@ -18,7 +18,7 @@ def schema_job_metadata(connection_test, prefix):
 
     class Source(dj.Lookup):
         definition = """
-        source_id : uint8
+        source_id : int16
         ---
         value : float32
         """
@@ -49,7 +49,7 @@ def make(self, key):
 
     class ManualTable(dj.Manual):
         definition = """
-        manual_id : uint8
+        manual_id : int16
         ---
         data : float32
         """
@@ -64,7 +64,7 @@ class ComputedWithPart(dj.Computed):
         class Detail(dj.Part):
             definition = """
             -> master
-            detail_idx : uint8
+            detail_idx : int16
             ---
             detail_value : float32
             """
@@ -237,7 +237,7 @@ def test_no_metadata_when_disabled(self, connection_test, prefix):
 
         class Source(dj.Lookup):
             definition = """
-            source_id : uint8
+            source_id : int16
             """
             contents = [(1,), (2,)]
 
diff --git a/tests/integration/test_type_aliases.py b/tests/integration/test_type_aliases.py
index 9aae0a8a9..cfa56052a 100644
--- a/tests/integration/test_type_aliases.py
+++ b/tests/integration/test_type_aliases.py
@@ -18,13 +18,9 @@ class TestTypeAliasPatterns:
             ("float32", "FLOAT32"),
             ("float64", "FLOAT64"),
             ("int64", "INT64"),
-            ("uint64", "UINT64"),
             ("int32", "INT32"),
-            ("uint32", "UINT32"),
             ("int16", "INT16"),
-            ("uint16", "UINT16"),
             ("int8", "INT8"),
-            ("uint8", "UINT8"),
             ("bool", "BOOL"),
         ],
     )
@@ -41,13 +37,9 @@ def test_type_alias_pattern_matching(self, alias, expected_category):
             ("float32", "float"),
             ("float64", "double"),
             ("int64", "bigint"),
-            ("uint64", "bigint unsigned"),
             ("int32", "int"),
-            ("uint32", "int unsigned"),
             ("int16", "smallint"),
-            ("uint16", "smallint unsigned"),
             ("int8", "tinyint"),
-            ("uint8", "tinyint unsigned"),
             ("bool", "tinyint"),
         ],
     )
@@ -73,6 +65,26 @@ def test_native_types_still_work(self, native_type, expected_category):
         category = match_type(native_type)
         assert category == expected_category
 
+    @pytest.mark.parametrize(
+        "native_type,expected_category",
+        [
+            ("int unsigned", "INTEGER"),
+            ("bigint unsigned", "INTEGER"),
+            ("smallint unsigned", "INTEGER"),
+            ("tinyint unsigned", "INTEGER"),
+        ],
+    )
+    def test_native_unsigned_types_pass_through(self, native_type, expected_category):
+        """
+        Test that native MySQL unsigned types are allowed as pass-through.
+
+        Note: These are MySQL-specific and not portable to PostgreSQL.
+        Users should prefer signed core types (int8, int16, int32, int64)
+        for cross-database compatibility.
+        """
+        category = match_type(native_type)
+        assert category == expected_category
+
 
 class TestTypeAliasTableCreation:
     """Test table creation with type aliases."""
@@ -102,13 +114,9 @@ def test_heading_preserves_type_aliases(self, schema_type_aliases):
         assert "float32" in heading_str
         assert "float64" in heading_str
         assert "int64" in heading_str
-        assert "uint64" in heading_str
         assert "int32" in heading_str
-        assert "uint32" in heading_str
         assert "int16" in heading_str
-        assert "uint16" in heading_str
         assert "int8" in heading_str
-        assert "uint8" in heading_str
         assert "bool" in heading_str
 
 
@@ -125,13 +133,9 @@ def test_insert_and_fetch(self, schema_type_aliases):
             val_float32=3.14,
             val_float64=2.718281828,
             val_int64=9223372036854775807,  # max int64
-            val_uint64=18446744073709551615,  # max uint64
             val_int32=2147483647,  # max int32
-            val_uint32=4294967295,  # max uint32
             val_int16=32767,  # max int16
-            val_uint16=65535,  # max uint16
             val_int8=127,  # max int8
-            val_uint8=255,  # max uint8
             val_bool=1,  # boolean true
         )
 
@@ -142,13 +146,9 @@ def test_insert_and_fetch(self, schema_type_aliases):
         assert abs(fetched["val_float32"] - test_data["val_float32"]) < 0.001
         assert abs(fetched["val_float64"] - test_data["val_float64"]) < 1e-9
         assert fetched["val_int64"] == test_data["val_int64"]
-        assert fetched["val_uint64"] == test_data["val_uint64"]
         assert fetched["val_int32"] == test_data["val_int32"]
-        assert fetched["val_uint32"] == test_data["val_uint32"]
         assert fetched["val_int16"] == test_data["val_int16"]
-        assert fetched["val_uint16"] == test_data["val_uint16"]
         assert fetched["val_int8"] == test_data["val_int8"]
-        assert fetched["val_uint8"] == test_data["val_uint8"]
         assert fetched["val_bool"] == test_data["val_bool"]
 
     def test_insert_primary_key_with_aliases(self, schema_type_aliases):
@@ -156,11 +156,11 @@ def test_insert_primary_key_with_aliases(self, schema_type_aliases):
         table = TypeAliasPrimaryKey()
         table.delete()
 
-        table.insert1(dict(pk_int32=100, pk_uint16=200, value="test"))
-        fetched = (table & dict(pk_int32=100, pk_uint16=200)).fetch1()
+        table.insert1(dict(pk_int32=100, pk_int16=200, value="test"))
+        fetched = (table & dict(pk_int32=100, pk_int16=200)).fetch1()
 
         assert fetched["pk_int32"] == 100
-        assert fetched["pk_uint16"] == 200
+        assert fetched["pk_int16"] == 200
         assert fetched["value"] == "test"
 
     def test_nullable_type_aliases(self, schema_type_aliases):
diff --git a/tests/schema.py b/tests/schema.py
index 4035e1211..f834d6eb7 100644
--- a/tests/schema.py
+++ b/tests/schema.py
@@ -67,7 +67,7 @@ class TTestNoExtra(dj.Manual):
 
 class Auto(dj.Lookup):
     definition = """
-    id  : uint8
+    id  : int16
     ---
     name :varchar(12)
     """
@@ -195,7 +195,7 @@ class Ephys(dj.Imported):
     class Channel(dj.Part):
         definition = """     # subtable containing individual channels
         -> master
-        channel    :uint8   # channel number within Ephys
+        channel    :int16   # channel number within Ephys
         ----
         voltage    : <blob>
         current = null : <blob>   # optional current to test null handling
diff --git a/tests/schema_simple.py b/tests/schema_simple.py
index f0e768d1f..8b31f96f9 100644
--- a/tests/schema_simple.py
+++ b/tests/schema_simple.py
@@ -143,7 +143,7 @@ class H(dj.Part):
     class M(dj.Part):
         definition = """ # test part_integrity cascade
         -> E
-        id_m : uint16
+        id_m : int32
         ---
         -> E.H
         """
diff --git a/tests/schema_type_aliases.py b/tests/schema_type_aliases.py
index eb586de5d..c6a785068 100644
--- a/tests/schema_type_aliases.py
+++ b/tests/schema_type_aliases.py
@@ -15,13 +15,9 @@ class TypeAliasTable(dj.Manual):
     val_float32 : float32     # 32-bit float
     val_float64 : float64     # 64-bit float
     val_int64 : int64         # 64-bit signed integer
-    val_uint64 : uint64       # 64-bit unsigned integer
     val_int32 : int32         # 32-bit signed integer
-    val_uint32 : uint32       # 32-bit unsigned integer
     val_int16 : int16         # 16-bit signed integer
-    val_uint16 : uint16       # 16-bit unsigned integer
     val_int8 : int8           # 8-bit signed integer
-    val_uint8 : uint8         # 8-bit unsigned integer
     val_bool : bool           # boolean value
     """
 
@@ -30,7 +26,7 @@ class TypeAliasPrimaryKey(dj.Manual):
     definition = """
     # Table with type alias in primary key
     pk_int32 : int32
-    pk_uint16 : uint16
+    pk_int16 : int16
     ---
     value : varchar(100)
     """
diff --git a/tests/schema_university.py b/tests/schema_university.py
index ac5ba4867..e07951282 100644
--- a/tests/schema_university.py
+++ b/tests/schema_university.py
@@ -5,7 +5,7 @@
 
 class Student(dj.Manual):
     definition = """
-    student_id : int unsigned   # university-wide ID number
+    student_id : int64   # university-wide ID number
     ---
     first_name      : varchar(40)
     last_name       : varchar(40)
@@ -41,7 +41,7 @@ class StudentMajor(dj.Manual):
 class Course(dj.Manual):
     definition = """
     -> Department
-    course  : int unsigned   # course number, e.g. 1010
+    course  : int64   # course number, e.g. 1010
     ---
     course_name :  varchar(200)  # e.g. "Neurobiology of Sensation and Movement."
     credits     :  decimal(3,1)  # number of credits earned by completing the course